Dry air is most important during the creation Too As throughout the storage of pharmaceutical products. Most materials used in drugs today are hygroscopic and any absorption of moisture throughout the production process will impact the final weight, quality and durability. When hygroscopic components are weighed and blended, it Is essential that the goods’ weight isn’t affected by absorption of moisture from the surrounding atmosphere. In powder form, moisture will affect the circulation, caking, Compaction and strength properties of the fabricated solid form. Yeast, bacteria and molds require a certain amount of Moisture to encourage growth. Controlling relative humidity is probably among the most important elements in maintaining a sterile environment. A cool dry environment generally enables quicker production, a better quality product and a longer shelf life. The vast majority of tableting processes require humidity control between 20 and 35%RH at 21 to 24°C.
In most pharmaceutical desiccant systems, the greatest moisture Load is from the new air component that is typically between 5 and 20 percent of the whole supply air volume. Based on moisture gains Throughout the area, it may only be necessary to deep dry the fresh air part with a pre-cooling coil > 10°Cdp and a desiccant dehumidifier. Dehumidifier capacity is controlled by an RH sensor installed in the return air duct. This simple design is often sufficient to keep the required RH within the room. Ac systems using a low fresh air volume and rooms with excessive moisture profits from high infiltration rates adverse room pressures, regular door use, product loading, etc, will normally require all of the fresh air and a percentage of the return air to be dried.
In Europe molecular sieve is used in pharmaceutical applications. In the United States it is often the desiccant of choice for pharmaceuticals and bio-chemicals and/or reagents. Although molecular sieve is slightly greater in price per unit because of its extremely large assortment of adsorptive capabilities and higher capacity at low relative humidity it is often the best value. Deficiency of Government approval for the molecular sieves in food and drug packaging has sadly limited its widespread use. Independent testing indicates that molecular sieves meet or exceed government requirements. Presumably, however, the sector has been reluctant to fund the costly and time consuming testing that is necessary for government approval.